Matt Bettonville

Current Position

Title: Investor, Director of Venture Investing, Health Company: Yosemite (formerly Emerson Collective) Location: San Francisco, CA

Professional Background

Matt Bettonville brings a unique blend of consumer technology expertise and healthcare innovation focus to his venture investing role. He began his career at Apple, where he worked on user interface software engineering for the Mac team and contributed to the AirPods product development—foundational experience that shaped his understanding of design, user experience, and the intersection of technology and hardware. He holds a Bachelor of Science in Computer Science from Stanford University with a focus on Human-Computer Interaction, equipping him with both technical depth and design thinking methodology.

Bettonville transitioned into healthcare innovation through his work at Emerson Collective, where he served as Software Engineering Manager and later in venture investing roles. Notably, he worked on the Count Me In non-profit partnership with the Broad Institute, a pioneering patient-partnered cancer research initiative that partnered with over 12,000 people with cancer. This experience marked his entry into the healthcare ecosystem and demonstrated his commitment to translating research breakthroughs into patient impact.

In 2023, he co-founded and joined Yosemite with Reed Jobs, a venture fund spun out of Emerson Collective with $263 million in capital dedicated to making cancer nonlethal. At Yosemite, he leads the digital health and healthcare delivery investment efforts alongside Yosemite's foundational grant-making model that de-risks early-stage academic science. His portfolio demonstrates a sophisticated understanding of healthcare's systemic challenges, from pricing transparency to care delivery innovation to emerging precision oncology technologies.

Career Timeline

Education

• B.S. in Computer Science (Human-Computer Interaction focus), Stanford University

Public Presence

Social Media

Note: LinkedIn is his primary professional platform with 500+ connections. X account exists but minimal activity. GitHub profile exists but dormant.

Published Writings

No traditional blog articles or published essays found in public sources. Bettonville primarily shares insights through:

• LinkedIn posts on portfolio company developments (Atropos Health ChatRWD TIME Best Invention, Daymark Health Series A, Fourier Health funding announcements, Teal Health cervical cancer screening)
• Attributed quotes in press releases and funding announcements
• Portfolio company blog posts featuring his investment commentary

Public Speaking

• "Can We Make Cancer Nonlethal?" — The Heart of Healthcare Podcast with Reed Jobs (2024)
• "Oncological Research and Drug Discovery Investments" — Breaking Health Podcast (year not specified)
• "Sci-Fi Stuff: Emerging Oncology Tech" — Medtech Insight / Citeline interview (2024)
• Various conference speaking on digital health and oncology investment thesis (implied through portfolio activity)

Communication Style

Tone: Pragmatic, accessible yet technically credible, solutions-oriented, enthusiastic about emerging technologies tempered by implementation realism

Recurring themes:

• Making cancer nonlethal / transforming cancer from lethal to manageable disease
• Healthcare system barriers (pricing, access, care delivery efficiency)
• Technology's role in democratizing medical expertise
• Patient-centric innovation
• Bridging academic research with clinical implementation

Notable positions:

• Strong advocate for pricing transparency in healthcare, particularly for high-cost cancer therapies
• Believes emerging oncology technologies (cell therapies, radiopharmaceuticals, precision diagnostics) require fundamental reimagining of care delivery infrastructure
• Sees AI and digital health as critical infrastructure for equitable cancer care access

Bettonville communicates with vivid, relatable language—he describes upcoming innovations as "really Sci-Fi stuff"—making complex biotechnology accessible without sacrificing technical credibility. His background in user interface design shows in his focus on practical implementation and system-level challenges rather than technology alone. In podcast interviews and articles, he demonstrates thoughtful problem-solving that acknowledges obstacles while maintaining genuine enthusiasm for solutions. His speech patterns suggest comfort moving between technical depth and accessible explanation, a reflection of his HCI training and cross-functional career path. He frames investments through the lens of patient impact and healthcare system transformation, not merely financial returns. Notably, he emphasizes that FDA approval is merely the beginning of implementation challenges, showing sophistication about the commercialization and delivery phases of healthcare innovation.

Notable Achievements

• Co-founded and leads digital health investing at Yosemite, a $263M oncology-focused venture fund with a novel grants + venture model
• Built Count Me In partnership with Broad Institute, engaging 12,000+ cancer patients in research
• Portfolio includes multiple companies recognized as TIME Best Inventions 2025 (Atropos Health, Teal Health)
• Board member at five healthcare companies: Atropos Health, Maia Oncology, Turquoise Health, Count Me In, Getlabs
• Directly influenced healthcare pricing transparency initiatives through Turquoise Health board involvement
• Transitioned from consumer hardware (Apple AirPods) to healthcare innovation, bridging distinct industries

Key Relationships

• Reed Jobs — Co-investor and co-founder at Yosemite, primary professional partnership
• Emerson Collective — Original institutional home; continues managing oncology investments through Yosemite
• Board roles:
  • Atropos Health (Series A board member through Yosemite investment)
  • Maia Oncology (precision medicine oncology)
  • Turquoise Health (healthcare pricing transparency platform)
  • Count Me In (patient-partnered cancer research nonprofit)
  • Getlabs (at-home lab testing)
• Academic connection: Broad Institute collaboration on Count Me In research initiative
• Investor network: Works with other Yosemite team members on digital health and healthcare delivery investments

Public Information Availability

Assessment: HIGH

Matt Bettonville maintains a moderate public profile appropriate to his role as a venture investor. Most public information comes from:

• Crunchbase and venture industry databases
• Press releases and funding announcements from portfolio companies
• Podcast interviews
• LinkedIn professional activity
• News coverage in health tech publications

No private social media profiles documented. GitHub account appears dormant. X account exists but inactive. Primary engagement through professional channels is consistent with venture investor norms.